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Nitric oxide then activates the enzyme guanylate cyclase, which leads to enhanced levels of cyclic guanosine monophosphate (cGMP), creating smooth muscle leisure during the corpus cavernosum and allowing for inflow of blood .

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Nonetheless, it can be done it's possible you'll experience far more critical Negative effects. In case you working experience any of the subsequent, call your doctor or 911 promptly:

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Medical professionals should really explore with patients the appropriate motion in the event that they expertise anginal upper body soreness requiring nitroglycerin next ingestion of CIALIS. In this type of affected person, who has taken CIALIS, exactly where nitrate administration is deemed medically necessary for a daily life-threatening predicament, no less than forty eight hrs should have elapsed after the previous dose of CIALIS just before nitrate administration is considered.

The proposed dose of CIALIS for as soon as day-to-day use is 5 mg, taken at about the identical time each day, devoid of regard to timing of sexual activity.

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